Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives e A review


Natural products have been used in conventional medicines for thousands of years, and have shown arrangement as a source of components for the loan of supplementary drugs. Turmeric (Curcuma longa Linn) is a enthusiast of the Zingiberaceae intimates and is cultivated in tropical and subtropical regions vis–vis the world and it is originates from India, Southeast Asia and Indonesia. Turmeric powder is used extensively as a coloring and flavoring agent in curries and mustards. Turmeric has been used in India to portion oral hygiene. It has traditionally been used for medical purposes for many centuries in countries such as India and China for treatment of jaundice and supplementary liver ailments. Turmeric is one of the most popular medicinal herbs, later than a broad range of pharmacological proceedings such as antioxidant,7 touching-protozoal, connected in the middle of-venom activities, all along-microbial, touching-malarial, touching-inflammatory, adjacent to-proliferative, the length of-angiogenic,14 in opposition to-tumor15 and versus-aging properties. It has in addition to been used to treat ulcers, parasiticinfections, various skin diseases, joined along in addition to-immune diseases and curing the symptoms of colds and flus. The pharmacological moving picture of turmeric has been credited mainly to curcuminoids consists of curcumin (CUR) and two similar compounds demethoxy curcumin (DMC) and bisdemethoxycurcumin (BDMC).3 CUR itself appears as a crystalline fused once a radiant ocher-orange color. Curcuminoids are commonly used as coloring agent as competently as food additives. World Health Organization (WHO) stated the sufficient daily intake of curcuminoids as a food association in the range of 0e3 mg/kg. Curcuminoids and turmeric products have been characterized as safe by the Food and Drug Administration (FDA) in USA. The average intake of turmeric in the Indian diet is since suggestion to 2e2.5 g for a 60 kg individual which corresponds to a daily intake of in the region of 60e100 mg of CUR. Curcuminoids have achieved the potential therapeutic whole to cure immune associated, metabolic diseases and cancer due to a earsplitting number of biological targets and roughly no side effects.

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