Cancer Cell Phase Arrest

Curcumin could furthermore do its stuff human breast cancer cells through inducing cell cycle arrest at the G2M phase and late S phase in MCF-7 cells. Curcumin led to an obvious late buildup of the G2M phase piece. Furthermore, Ke et al.65 indicated that the percentage of cells arrested in the G2 phase and late S phase increased along later than an gathering of curcumin dose. Curcumin with acted similarly to Aurora-A SiRNA (small interfering RNA), leading to monopolar spindle formation, S and G2/M arrest, and cell detachment reduction in MCF-7 cells. Curcumin induces cancer cell phase arrest through changeable spindle-connected signaling pathways. A perplexing effect a propos mitotic spindle paperwork was exerted by curcumin directly, and the monopolar spindles were formed. Consequently, chromosomes were not able to be segregated normally and cells were arrested in the M phase. Alternatively, curcumin with affected the freshening levels of spindle motor protein indirectly, including the Xenopus laevis/Aurora/Ip11p-Related Kinase pEg2. Phosphorylation of Eg5 regulated the scuffle of the spindle motor protein, and downregulation of pEg2 resulted in monopolar spindles.
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