Curcumin in Treating Breast Cancer: A Review Introduction

Breast cancer is the most commonly diagnosed malignant tumor and the second leading cause of cancer mortality in the middle of women in the United States.1 About 70% of breast cancers are classified as estrogen receptor (ER) be down and could be treated considering antiestrogens.2,3 Recently, growing evidence has indicated that the application of a single molecule can hardly suppress the furious chat and negative feedback loops in the merged cancer cellular networks.4 Therefore, drug combinations targeting exchange pathology signaling pathways have been considered as a major trend in drug design and discovery for killing endocrine-resistant breast cancer cells.5 Yet, both the research and clinical applications are yet in pleasing habit of energetic candidates for improved treatment of breast cancer.

Curcumin is a hydrophobic polyphenol derived from turmeric, a usual Indian spice6 (Fig. 1). Curcumin has been used as an ethnic drug for the treatment of diverse diseases. Particularly, curcumin has been venerated as an thriving anticancer agent that regulates collective intracellular signaling pathways, including transcription factors (e.g., STAT3, NF-B, and AP-1), receptors (e.g., IL-8, HER2, and CXCR4), kinases (e.g., EGFR, ERK, and JAK), cytokines (e.g., TNF, IL, and MIP), enzymes (e.g., MMP, iNOS, and GST), and exaggeration factors (e.g., EGF, NGF, and HGF).7 Yet, the discussions on curcumins anticancer effects have by yourself been straightforward in the last few decades. Sharma et al.8 succeeded in treating colorectal cancer in the since curcumin in phase I, and Cruz-Correa et al.9 used curcumin in the treatment of patients who were diagnosed behind family adenomatous polyposis. In anexperimental scrutiny of mammary cancer induced by 7,12-dimethylbenzanthracene (DMBA), curcumin significantly decreased the opening of mammary adenocarcinoma just more or less the fourth day after DMBA administration.10 Furthermore, a large number of studies upon cancer prevention at every choice stages have indicated curcumin as a appreciative agent for cancer chemoprevention, used both alone and in assimilation like new drugs.

Although healthy lifestyles, including balanced diets, regular exercise, alcohol lessening, smoking cessation, and emphasize supervision, have proved their support in preventing merged kinds of cancer,1418 the U.S. Food and Drug Administration (FDA) commendation of tamoxifen, a selective estrogen receptor modulator (SERM), is considered to be a milestone in breast cancer chemoprevention.19 When a potential drug complex is under scrutiny, the utmost importance should always be the safety issue. In this context, unlike synthetic compounds, natural products expertise in fruits and vegetables possess natural advantages. As such, the numerous effects of curcumin, including antioxidation and anti-inflammation, have called for extensive research efforts in recent years. In the subsequent to parts of this article, we review and summarize the recent publications in eight categories according to curcumin diversified functions upon breast cancer.

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