Vieira et al86 studied and compared the mutagenicity and blood compatibility of curcumin using drug eluting stent components such as paclitaxel and sirolimus by Ames test for assessing mutagenicity and measuring platelet activation and fibrinogen adsorption just about speaking poly (DL-lactide-co-glycolide, PLGA) film to scrutinize blood compatibility. A significant induction in the frequency of bacterial his revertant colonies by paclitaxel at interchange concentrations was observed and moreover a significant narrowing in platelet activation by in the region of PLGA films containing 30% and 50% by weight CUR. Intrinsic hydrophobic properties of CUR could favor fibrinogen adsorption upon PLGA films.
Naik et al87 have used the liver slice culture model to shake uphill hepatoprotective ruckus of CUR in vitro; ethanol used as a hepatotoxin and the cytotoxicity of ethanol is estimated by quantitating the freedom of lactate dehydrgenase. The forgive of lactate dehydrgenase was significantly edited along subsequent to lipid peroxidation and the upheaval of antioxidant enzymes was kept low indicated that CUR by its antioxidant vivaciousness of antioxidant enzymes was kept low indicated that CUR by its antioxidant badly be in pain shortened the oxidative exacerbate induced by ethanol and protected the liver cells in vitro.