Sexually transmitted infections

Sexually transmitted infections and inadvertent pregnancies gift a pleasant risk to the reproductive health of women. Female controlled vaginal products directed toward sickness prevention and contraception is needed urgently. Patel et al71 developed poloxamer based thermo suffering contraceptive vaginal in situ hydrogel of CUR, a forest derived CUR fused. Biodegradable hydrogels impregnated gone Poloxamers and HPMC K4M could next to the proceed of a non-hormonal, women approachable, long acting and biocompatible intravaginal contraceptive dosage form. The dosage form was optimized using a three-factor, three-level Box-Behnken Design (BBD). From BBD, it is concluded that batch containing 19.96% Poloxamer 407, 3.83% Poloxamer 188, 0.91% HPMC K4M was optimized, which could have maximum quarters period, fine efficacy in terms of contraception and highest fan submission. The dosage form could be used additionally as a spermicide inside a condom. CUR showed many beneficial effects with Clomiphene citrate in treating polycystic ovary syndrome (PCOS) condition and inducing ovulation. CUR restored the hormone and lipid profile, antioxidant and glycemic status as competently as ovarian morphology in Letrozole induced PCOS animals due to its join up pharmacological behavior which could be useful in managing PCOS condition and prevent ovarian cell dysfunction, ovulation and thereby improving fertility. CUR can be a promising drug for treating clinical and pathological abnormalities in PCOS condition.72 Akinyemi et al73 investigated the preventive effects of turmeric rhizomes upon some biomarkers of male reproductive play in L-NAME-induced hypertensive rats. Dietary supplementation once turmeric rhizome was allied gone restoration of systolic blood pressure, sperm motility, testosterone level and an take prematurely of antioxidant status in the epididymides and testes of L-NAME-induced hypertensive rats. Turmeric rhizomes could be harnessed as active foods to prevent hypertension-mediated male reproductive dysfunction.
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